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Practical articles on propolis in the treatment of cancer

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  1. Tao L, et al. Chinese Propolis Suppressed Pancreatic Cancer Panc-1 Cells Proliferation and Migration via Hippo-YAP Pathway. Molecules. 2021;26(9).
  2. Sameni HR, et al. Co-administration of 5FU and propolis on AOM/DSS induced colorectal cancer in BALB-c mice. Life Sci. 2021;276:119390.
  3. Rouibah H, et al. Algerian propolis: between protection of normal cells and potentialisation of the anticancer effects of doxorubicin against breast cancer cells via P-glycoprotein inhibition and cell cycle arrest in the S phase. J Physiol Pharmacol. 2021;72(2).
  4. Onur E, et al. Investigation of the supportive therapy potential of propolis extract and Lactobacillus acidophilus LA-5 milk combination against breast cancer in mice. Cytokine. 2021;149:155743.
  5. Niyomtham N, et al. Apis mellifera propolis enhances apoptosis and invasion inhibition in head and neck cancer cells. PeerJ. 2021;9:e12139.
  6. Masadah R, et al. Effects of propolis and its bioactive components on breast cancer cell pathways and the molecular mechanisms involved. Breast Dis. 2021;40(S1):S15-S25.
  7. Forma E, et al. Anticancer Activity of Propolis and Its Compounds. Nutrients. 2021;13(8).
  8. Davoodi SH, et al. Oral Propolis, Nutritional Status and Quality of Life with Chemotherapy for Breast Cancer: A Randomized, Double-Blind Clinical Trial. Nutr Cancer. 2021:1-9.
  9. Cetin EO, et al. Preparation of Ethanol Extract of Propolis Loaded Niosome Formulation and Evaluation of Effects on Different Cancer Cell Lines. Nutr Cancer. 2021:1-13.
  10. Campos JF, et al. Stingless Bee Propolis: New Insights for Anticancer Drugs. Oxid Med Cell Longev. 2021;2021:2169017.
  11. Campoccia D, et al. Exploring the anticancer effects of standardized extracts of poplar-type propolis: In vitro cytotoxicity toward cancer and normal cell lines. Biomed Pharmacother. 2021;141:111895.
  12. Botteon CEA, et al. Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities. Sci Rep. 2021;11(1):1974.
  13. Alsherbiny MA, et al. Metabolomic Identification of Anticancer Metabolites of Australian Propolis and Proteomic Elucidation of Its Synergistic Mechanisms with Doxorubicin in the MCF7 Cells. Int J Mol Sci. 2021;22(15).
  14. Al-Fakeh MS, et al. Characterization, Antimicrobial and Anticancer Properties of Palladium Nanoparticles Biosynthesized Optimally Using Saudi Propolis. Nanomaterials (Basel). 2021;11(10).
  15. Alanazi S, et al. Chemical characterization of Saudi propolis and its antiparasitic and anticancer properties. Sci Rep. 2021;11(1):5390.
  16. Zingue S, et al. Ethanol-extracted Cameroonian propolis: Antiproliferative effects and potential mechanism of action in prostate cancer. Andrologia. 2020;52(9):e13698.
  17. Wezgowiec J, et al. Polish Propolis-Chemical Composition and Biological Effects in Tongue Cancer Cells and Macrophages. Molecules. 2020;25(10).
  18. Tatli Seven P, et al. Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer. Plants (Basel). 2020;9(9).
  19. Salem MM, et al. Propolis Potentiates Methotrexate Anticancer Mechanism and Reduces its Toxic Effects. Nutr Cancer. 2020;72(3):460-80.
  20. Misir S, et al. Effect of Turkish Propolis on miRNA Expression, Cell Cycle, and Apoptosis in Human Breast Cancer (MCF-7) Cells. Nutr Cancer. 2020;72(1):133-45.
  21. Jiang XS, et al. Chinese Propolis Inhibits the Proliferation of Human Gastric Cancer Cells by Inducing Apoptosis and Cell Cycle Arrest. Evid Based Complement Alternat Med. 2020;2020:2743058.
  22. Ilhan-Ayisigi E, et al. Nano-vesicular formulation of propolis and cytotoxic effects in a 3D spheroid model of lung cancer. J Sci Food Agric. 2020;100(8):3525-35.
  23. Gajek G, et al. Antagonistic Effects of CAPE (a Component of Propolis) on the Cytotoxicity and Genotoxicity of Irinotecan and SN38 in Human Gastrointestinal Cancer Cells In Vitro. Molecules. 2020;25(3).
  24. Frion-Herrera Y, et al. The Cuban Propolis Component Nemorosone Inhibits Proliferation and Metastatic Properties of Human Colorectal Cancer Cells. Int J Mol Sci. 2020;21(5).
  25. Frion-Herrera Y, et al. Cuban Brown Propolis Interferes in the Crosstalk between Colorectal Cancer Cells and M2 Macrophages. Nutrients. 2020;12(7).
  26. Assumpcao JHM, et al. Effects of Propolis and Phenolic Acids on Triple-Negative Breast Cancer Cell Lines: Potential Involvement of Epigenetic Mechanisms. Molecules. 2020;25(6).
  27. Amalia E, et al. Water-soluble propolis and bee pollen of Trigona spp. from South Sulawesi Indonesia induce apoptosis in the human breast cancer MCF-7 cell line. Oncol Lett. 2020;20(5):274.
  28. Touzani S, et al. In Vitro Evaluation of the Potential Use of Propolis as a Multitarget Therapeutic Product: Physicochemical Properties, Chemical Composition, and Immunomodulatory, Antibacterial, and Anticancer Properties. Biomed Res Int. 2019;2019:4836378.
  29. Seyhan MF, et al. Different propolis samples, phenolic content, and breast cancer cell lines: Variable cytotoxicity ranging from ineffective to potent. IUBMB Life. 2019;71(5):619-31.
  30. Frion-Herrera Y, et al. The cytotoxic effects of propolis on breast cancer cells involve PI3K/Akt and ERK1/2 pathways, mitochondrial membrane potential, and reactive oxygen species generation. Inflammopharmacology. 2019;27(5):1081-9.
  31. Chen WT, et al. Thermal cycling as a novel thermal therapy to synergistically enhance the anticancer effect of propolis on PANC1 cells. Int J Oncol. 2019;55(3):617-28.
  32. Asgharpour F, et al. Iranian propolis efficiently inhibits growth of oral streptococci and cancer cell lines. BMC Complement Altern Med. 2019;19(1):266.
  33. Abutaha N. Apoptotic Potential and Chemical Composition of Jordanian Propolis Extract against Different Cancer Cell Lines. J Microbiol Biotechnol. 2019;30(6):893-902.
  34. Vukovic NL, et al. Cytotoxic, proapoptotic and antioxidative potential of flavonoids isolated from propolis against colon (HCT-116) and breast (MDA-MB-231) cancer cell lines. Food Res Int. 2018;106:71-80.
  35. Sherif MS, et al. Cytotoxicity of propolis nanopreparations in cancer cell monolayers: multimode of action including apoptotsis and nitric oxide production. Gen Physiol Biophys. 2018;37(1):101-10.
  36. Rouibah H KWLMZMAMABMEE-AHJ. Erratum to Algerian Propolis Potentiates Doxorubicin Mediated Anticancer Effect Against Human Pancreatic PANC-1 Cancer Cell Line through Cell Cycle Arrest, Apoptosis Induction and P-Glycoprotein Inhibition. Anticancer Agents Med Chem. 2018;18(9):1364.
  37. Rouibah H, et al. Algerian Propolis Potentiates Doxorubicin Mediated Anticancer Effect Against Human Pancreatic PANC-1 Cancer Cell Line through Cell Cycle Arrest, Apoptosis Induction and P-Glycoprotein Inhibition. Anticancer Agents Med Chem. 2018;18(3):375-87.
  38. Nani BD, et al. Isoflavonoids from Brazilian red propolis down-regulate the expression of cancer-related target proteins: A pharmacogenomic analysis. Phytother Res. 2018;32(4):750-4.
  39. Mitsui T, et al. Chemical constituents of Brazilian Propolis from the state of Bahia and their growth inhibitory activities against cancer cells. Biosci Biotechnol Biochem. 2018;82(3):417-21.
  40. Kuo CC, et al. Meta-analysis of randomized controlled trials of the efficacy of propolis mouthwash in cancer therapy-induced oral mucositis. Support Care Cancer. 2018;26(12):4001-9.
  41. Kabala-Dzik A, et al. Flavonoids, bioactive components of propolis, exhibit cytotoxic activity and induce cell cycle arrest and apoptosis in human breast cancer cells MDA-MB-231 and MCF-7 – a comparative study. Cell Mol Biol (Noisy-le-grand). 2018;64(8):1-10.
  42. Ishida Y, et al. Anticancer Activity in Honeybee Propolis: Functional Insights to the Role of Caffeic Acid Phenethyl Ester and Its Complex With gamma-Cyclodextrin. Integr Cancer Ther. 2018;17(3):867-73.
  43. Ippolito E, et al. Efficacy of a Propolis-Based Syrup (FARINGEL) in Preventing Radiation-Induced Esophagitis in Locally Advanced Lung Cancer. Chemotherapy. 2018;63(2):76-82.
  44. Endo S, et al. Autophagy inhibition enhances anticancer efficacy of artepillin C, a cinnamic acid derivative in Brazilian green propolis. Biochem Biophys Res Commun. 2018;497(1):437-43.
  45. Bhargava P, et al. Anticancer activity of the supercritical extract of Brazilian green propolis and its active component, artepillin C: Bioinformatics and experimental analyses of its mechanisms of action. Int J Oncol. 2018;52(3):925-32.
  46. Utispan K, et al. Cytotoxic Activity of Propolis Extracts from the Stingless Bee Trigona Sirindhornae Against Primary and Metastatic Head and Neck Cancer Cell Lines. Asian Pac J Cancer Prev. 2017;18(4):1051-5.
  47. Takahashi H, et al. 1,2,3-Triazolyl esterization of PAK1-blocking propolis ingredients, artepillin C (ARC) and caffeic acid (CA), for boosting their anti-cancer/anti-PAK1 activities along with cell-permeability. Drug Discov Ther. 2017;11(2):104-9.
  48. Piredda M, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6).
  49. Nguyen HX, et al. Chemical Constituents of Propolis from Vietnamese Trigona minor and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line. J Nat Prod. 2017;80(8):2345-52.
  50. Nguyen BCQ, et al. Frondoside A from sea cucumber and nymphaeols from Okinawa propolis: Natural anti-cancer agents that selectively inhibit PAK1 in vitro. Drug Discov Ther. 2017;11(2):110-4.
  51. Kustiawan PM, et al. Molecular mechanism of cardol, isolated from Trigona incisa stingless bee propolis, induced apoptosis in the SW620 human colorectal cancer cell line. BMC Pharmacol Toxicol. 2017;18(1):32.
  52. Kabala-Dzik A, et al. Comparison of Two Components of Propolis: Caffeic Acid (CA) and Caffeic Acid Phenethyl Ester (CAPE) Induce Apoptosis and Cell Cycle Arrest of Breast Cancer Cells MDA-MB-231. Molecules. 2017;22(9).
  53. Frozza C, et al. Antitumor activity of Brazilian red propolis fractions against Hep-2 cancer cell line. Biomed Pharmacother. 2017;91:951-63.
  54. Chang H, et al. Ethanol extract of propolis and its constituent caffeic acid phenethyl ester inhibit breast cancer cells proliferation in inflammatory microenvironment by inhibiting TLR4 signal pathway and inducing apoptosis and autophagy. BMC Complement Altern Med. 2017;17(1):471.
  55. Taira N, et al. Effect of Okinawa Propolis on PAK1 Activity, Caenorhabditis elegans Longevity, Melanogenesis, and Growth of Cancer Cells. J Agric Food Chem. 2016;64(27):5484-9.
  56. Patel S. Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents. J Diet Suppl. 2016;13(3):245-68.
  57. Khacha-Ananda S, et al. Propolis extracts from the northern region of Thailand suppress cancer cell growth through induction of apoptosis pathways. Invest New Drugs. 2016;34(6):707-22.
  58. Elbaz NM, et al. Chitosan-based nano-in-microparticle carriers for enhanced oral delivery and anticancer activity of propolis. Int J Biol Macromol. 2016;92:254-69.
  59. Demir S, et al. Antiproliferative and proapoptotic activity of Turkish propolis on human lung cancer cell line. Nutr Cancer. 2016;68(1):165-72.
  60. AkhavanKarbassi MH, et al. Randomized DoubleBlind PlaceboControlled Trial of Propolis for Oral Mucositis in Patients Receiving Chemotherapy for Head and Neck Cancer. Asian Pac J Cancer Prev. 2016;17(7):3611-4.
  61. Salim EI, et al. Antitumoral and Antioxidant Potential of Egyptian Propolis Against the PC3 Prostate Cancer Cell Line. Asian Pac J Cancer Prev. 2015;16(17):7641-51.
  62. Sadeghi-Aliabadi H, et al. Investigation of Astragalus honey and propolis extract’s cytotoxic effect on two human cancer cell lines and their oncogen and proapoptotic gene expression profiles. Adv Biomed Res. 2015;4:42.
  63. Rzepecka-Stojko A, et al. Caffeic Acid phenethyl ester and ethanol extract of propolis induce the complementary cytotoxic effect on triple-negative breast cancer cell lines. Molecules. 2015;20(5):9242-62.
  64. Kustiawan PM, et al. Propolis from the Stingless Bee Trigona incisa from East Kalimantan, Indonesia, Induces In Vitro Cytotoxicity and Apoptosis in Cancer Cell lines. Asian Pac J Cancer Prev. 2015;16(15):6581-9.
  65. Kubina R, et al. The Ethanol Extract of Polish Propolis Exhibits Anti-Proliferative and/or Pro-Apoptotic Effect on HCT 116 Colon Cancer and Me45 Malignant Melanoma Cells In Vitro Conditions. Adv Clin Exp Med. 2015;24(2):203-12.
  66. Javadzadeh Bolouri A, et al. Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers: A Triple-Blind, Randomized, Placebo-Controlled Trial. Iran J Cancer Prev. 2015;8(5):e4019.
  67. Frion-Herrera Y, et al. Brazilian green propolis induced apoptosis in human lung cancer A549 cells through mitochondrial-mediated pathway. J Pharm Pharmacol. 2015;67(10):1448-56.
  68. de Mendonca IC, et al. Brazilian red propolis: phytochemical screening, antioxidant activity and effect against cancer cells. BMC Complement Altern Med. 2015;15:357.
  69. Buahorm S, et al. Cardanol isolated from Thai Apis mellifera propolis induces cell cycle arrest and apoptosis of BT-474 breast cancer cells via p21 upregulation. Daru. 2015;23:55.
  70. Alizadeh AM, et al. Chemoprotection of MNNG-initiated gastric cancer in rats using Iranian propolis. Arch Iran Med. 2015;18(1):18-23.
  71. Xuan H, et al. Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells. Evid Based Complement Alternat Med. 2014;2014:280120.
  72. S VK. Propolis in dentistry and oral cancer management. N Am J Med Sci. 2014;6(6):250-9.
  73. Begnini KR, et al. Brazilian red propolis induces apoptosis-like cell death and decreases migration potential in bladder cancer cells. Evid Based Complement Alternat Med. 2014;2014:639856.
  74. Valenca I, et al. Portuguese propolis disturbs glycolytic metabolism of human colorectal cancer in vitro. BMC Complement Altern Med. 2013;13:184.
  75. Szliszka E, et al. Ethanolic Extract of Polish Propolis: Chemical Composition and TRAIL-R2 Death Receptor Targeting Apoptotic Activity against Prostate Cancer Cells. Evid Based Complement Alternat Med. 2013;2013:757628.
  76. Szliszka E, et al. Polyphenols Isolated from Propolis Augment TRAIL-Induced Apoptosis in Cancer Cells. Evid Based Complement Alternat Med. 2013;2013:731940.
  77. Omene C, et al. Propolis and its Active Component, Caffeic Acid Phenethyl Ester (CAPE), Modulate Breast Cancer Therapeutic Targets via an Epigenetically Mediated Mechanism of Action. J Cancer Sci Ther. 2013;5(10):334-42.
  78. Markiewicz-Zukowska R, et al. Propolis changes the anticancer activity of temozolomide in U87MG human glioblastoma cell line. BMC Complement Altern Med. 2013;13:50.
  79. Khacha-ananda S, et al. Antioxidant and anti-cancer cell proliferation activity of propolis extracts from two extraction methods. Asian Pac J Cancer Prev. 2013;14(11):6991-5.
  80. Diaz-Carballo D, et al. Multi-targeted polycyclic polyprenylated acylphloroglucinols are major constituents of Cuban propolis and contributors to its anticancer activity. Int J Clin Pharmacol Ther. 2013;51(1):54-5.
  81. Choudhari MK, et al. Anticancer activity of Indian stingless bee propolis: an in vitro study. Evid Based Complement Alternat Med. 2013;2013:928280.
  82. Chan GC, et al. The immunomodulatory and anticancer properties of propolis. Clin Rev Allergy Immunol. 2013;44(3):262-73.
  83. Acikelli AH, et al. Flavonoids isolated from Caribbean propolis show cytotoxic activity in human cancer cell lines. Int J Clin Pharmacol Ther. 2013;51(1):51-3.
  84. Teerasripreecha D, et al. In vitro antiproliferative/cytotoxic activity on cancer cell lines of a cardanol and a cardol enriched from Thai Apis mellifera propolis. BMC Complement Altern Med. 2012;12:27.
  85. Sun LP, et al. Chrysin: a histone deacetylase 8 inhibitor with anticancer activity and a suitable candidate for the standardization of Chinese propolis. J Agric Food Chem. 2012;60(47):11748-58.
  86. Sawicka D, et al. The anticancer activity of propolis. Folia Histochem Cytobiol. 2012;50(1):25-37.
  87. Omene CO, et al. Caffeic Acid Phenethyl Ester (CAPE) derived from propolis, a honeybee product, inhibits growth of breast cancer stem cells. Invest New Drugs. 2012;30(4):1279-88.
  88. Kamiya T, et al. Ethanol extract of Brazilian red propolis induces apoptosis in human breast cancer MCF-7 cells through endoplasmic reticulum stress. J Agric Food Chem. 2012;60(44):11065-70.
  89. Dornelas CA, et al. Chemoprevention with green propolis green propolis extracted in L-lysine versus carcinogenesis promotion with L-lysine in N-Butyl-N-[4-hydroxybutyl] nitrosamine (BBN) induced rat bladder cancer. Acta Cir Bras. 2012;27(2):185-92.
  90. Dornelas CA, et al. Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine on bladder cancer in rats. Acta Cir Bras. 2012;27(8):529-36.
  91. Chen CN, et al. Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis. Nat Prod Res. 2012;26(2):116-24.
  92. Wu J, et al. Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer. Cancer Lett. 2011;308(1):43-53.
  93. Watanabe MA, et al. Cytotoxic constituents of propolis inducing anticancer effects: a review. J Pharm Pharmacol. 2011;63(11):1378-86.
  94. Valente MJ, et al. Biological activities of Portuguese propolis: protection against free radical-induced erythrocyte damage and inhibition of human renal cancer cell growth in vitro. Food Chem Toxicol. 2011;49(1):86-92.
  95. Umthong S, et al. In vitro antiproliferative activity of partially purified Trigona laeviceps propolis from Thailand on human cancer cell lines. BMC Complement Altern Med. 2011;11:37.
  96. Szliszka E, et al. Ethanolic extract of Brazilian green propolis sensitizes prostate cancer cells to TRAIL-induced apoptosis. Int J Oncol. 2011;38(4):941-53.
  97. Szliszka E, et al. Ethanolic Extract of Propolis Augments TRAIL-Induced Apoptotic Death in Prostate Cancer Cells. Evid Based Complement Alternat Med. 2011;2011:535172.
  98. Barlak Y, et al. Effect of Turkish propolis extracts on proteome of prostate cancer cell line. Proteome Sci. 2011;9:74.
  99. Li F, et al. Cytotoxicity of constituents from Mexican propolis against a panel of six different cancer cell lines. Nat Prod Commun. 2010;5(10):1601-6.
  100. Li F, et al. Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells. J Nat Prod. 2010;73(4):623-7.
  101. Kouidhi B, et al. Anti-cariogenic and anti-biofilms activity of Tunisian propolis extract and its potential protective effect against cancer cells proliferation. Anaerobe. 2010;16(6):566-71.
  102. Szliszka E, et al. Ethanolic extract of propolis (EEP) enhances the apoptosis- inducing potential of TRAIL in cancer cells. Molecules. 2009;14(2):738-54.
  103. Popolo A, et al. Antiproliferative activity of brown Cuban propolis extract on human breast cancer cells. Nat Prod Commun. 2009;4(12):1711-6.
  104. Li F, et al. Chemical constituents of propolis from Myanmar and their preferential cytotoxicity against a human pancreatic cancer cell line. J Nat Prod. 2009;72(7):1283-7.
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